MCIDAS Antibody, Biotin conjugated

Code CSB-PA518689LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MCIDAS Polyclonal antibody
Uniprot No.
Target Names
MCIDAS
Alternative Names
IDAS antibody; Mci antibody; MCI_HUMAN antibody; Multicilin antibody; Protein Idas antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Multicilin protein (3-110AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway. Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1.
Gene References into Functions
  1. MCIDAS mutations result in a mucociliary clearance disorder with reduced generation of multiple motile cilia.MCIDAS regulates CCNO and FOXJ1 expression. PMID: 25048963
  2. The properties of the Idas-Geminin complex suggest it as the functional form of Idas and provide a possible mechanism to modulate Geminin activity PMID: 24064211
  3. Idas as a novel Geminin binding partner, implicated in cell cycle progression, and a putative regulator of proliferation-differentiation decisions during development. PMID: 21543332
Subcellular Location
Nucleus.
Protein Families
Geminin family
Database Links

HGNC: 40050

OMIM: 614086

KEGG: hsa:345643

STRING: 9606.ENSP00000426359

UniGene: Hs.394578

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